Excess Weight, Obesity, Diabetes (Type-2), and Clinical Complications

GENETIC BASIS OF TYpE 1 DIABETES, TYpE 2 DIABETES, OBESITY, AND THEIR COMPlICATIONS contents:

Obesity and type 2 diabetes

Obesity and type 2 diabetes (T2DM) are public health problems, with health consequences and economic costs that have raised concern worldwide. The increase in the prevalence of diabetes parallels that of obesity. Some experts call this dual epidemic “diabesity”. Elevated body mass index (BMI) and waist circumference (WC) were significantly associated T2DM. One consequence of obesity is an incre...

Common Variations in Perilipin rs1052700 and FTO rs3751812 Genes, Central Obesity, and Risk Type-2 Diabetes

Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-2 diabetes (T2D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T2D was investigated. Methods: Clinical traits in a random sample of 183 Iranian men and wom...

Serum Adiponectin and Vaspin levels in Abdominal Obesity and Type 2 Diabetes Mellitus

Abstract Objective: Adiponectin and vaspin are adipocyte-derived proteins and involved in the regulation of glucose metabolism and obesity related disorders. The mechanisms that adipokines might be linked to disturbance of glucose are unclear. Thus, this study investigated the levels of serum adiponectin and vaspin, blood lipid profiles, and abdominal obesity in type 2 diabetes (T2DM) patients...

Type 2 Diabetes Mellitus and Macrovascular Complications

Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Division of Internal Medicine, Rambam Health Care Campus and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel Institute of Endocrinology, Diabete...